New Publication in Cancer Research

I co-authored an article in Cancer Research entitled “Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification” led by Dr. Aubrey Hubbard. We investigated whether inclusion of a chronic lymphocytic leukemia (CLL)-associated polygenic score and two common types of clonal hematopoiesis (i.e., autosomal mosaic chromosomal alterations and clonal hematopoiesis indeterminate potential), could improve CLL risk stratification in the UK Biobank. We also replicated our investigation in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We obtained enhanced ability to identify individuals at high risk of CLL when integrating germline and somatic data derived from peripheral blood.